Ferri C, De Angelis C, Del Porto M A, Leonetti Luparini R, Giarrizzo C, Santucci A, Balsano F
Università di Roma La Sapienza, Istituto di l Clinica Medica, Rome, Italy.
J Hypertens Suppl. 1988 Nov;6(1):S117-9.
We evaluated the effect of nicardipine treatment on platelet angiotensin II content in 18 essential hypertensive patients. Nicardipine induced a decrease in platelet angiotensin II content in all patients (-14%), but particularly in 10 (P less than 0.05; -20.5%). No other differences were found between these patients and the others. Further investigations are required to determine whether platelet angiotensin II content reduction contributes to the prophylactic and therapeutic effects of calcium antagonists on atherosclerosis.
我们评估了尼卡地平治疗对18例原发性高血压患者血小板血管紧张素II含量的影响。尼卡地平使所有患者的血小板血管紧张素II含量均有所降低（-14%），但在10例患者中降低尤为明显（P<0.05；-20.5%）。这些患者与其他患者之间未发现其他差异。需要进一步研究以确定血小板血管紧张素II含量降低是否有助于钙拮抗剂对动脉粥样硬化的预防和治疗作用。
