Moore M R
Postgrad Med J. 1975 Nov;51(601):760-4. doi: 10.1136/pgmj.51.601.760.
In studies on the distribution of lead in rats given drinking water containing lead acetate at concentrations: 0, 100, 500, 1000 and 5000 μgPb/l for one year, no change was observed in the organ distribution of lead, or in the subcellular distribution of lead in the organelles in the heart. The mitochondrial enzyme, ferrochelatase, was significantly depressed in both the 500 and 1000 μg/l groups as was the cytoplasmic enzyme δ-aminolaevulinic acid dehydratase. These depressions of enzyme activity were associated with ultrastructural changes in the myocardium after six months, and were most pronounced in the mitochondria.
在一项研究中，给大鼠饮用含醋酸铅浓度分别为0、100、500、1000和5000μgPb/l的水，持续一年，结果发现铅在大鼠体内的器官分布，以及心脏细胞器内铅的亚细胞分布均未发生变化。线粒体酶铁螯合酶在500μg/l和1000μg/l组中均显著降低，细胞质酶δ-氨基乙酰丙酸脱水酶也是如此。酶活性的这些降低与六个月后心肌的超微结构变化有关，且在线粒体中最为明显。
