Philipp-Dormston W K, Doss M
Z Naturforsch C Biosci. 1975 May-Jun;30(3):425-6. doi: 10.1515/znc-1975-5-624.
In Escherichia coli, Pseudomonas aeruginosa, and Achromobacter metalcaligenes gamma-aminolevulinic acid synthase and gamma-aminolevulinic acid dehydratase appear to be the rate limiting enzymes of porphyrin and heme biosynthesis. Bypassing of these enzymes by addition of gamma-aminolevulinic acid or porphobilinogen results in overproduction of tetrapyrroles.
在大肠杆菌、铜绿假单胞菌和产碱无色杆菌中,γ-氨基乙酰丙酸合酶和γ-氨基乙酰丙酸脱水酶似乎是卟啉和血红素生物合成的限速酶。通过添加γ-氨基乙酰丙酸或胆色素原绕过这些酶会导致四吡咯的过量产生。