Barltrop D, Meek F
Postgrad Med J. 1975 Nov;51(601):805-9. doi: 10.1136/pgmj.51.601.805.
A rapid method for the determination of relative absorption of dietary lead by rats is described. The influence of age, weight and dose rate has been determined and using standard conditions the tissue lead content of blood, kidney and femur are significantly correlated with each other and are a function of ingested lead. Eight lead compounds were evaluated using this technique and the findings related to lead acetate as a reference compound. Of the inorganic preparations studied, lead carbonate (basic) and metallic lead showed a twelve-fold difference in absorption, with the remaining compounds giving intermediate values. The absorption of lead from four organic compounds was determined from diets containing 7·5% corn oil added to the standard diet. Lead tallate was absorbed to the same degree as lead acetate, but lesser absorptions resulted from lead octoate, naphthenate and alsynate. The addition of corn oil to a final concentration of 7·5% of the diet enhanced the absorption of lead acetate.
本文描述了一种快速测定大鼠膳食铅相对吸收量的方法。已确定年龄、体重和剂量率的影响，在标准条件下，血液、肾脏和股骨中的组织铅含量彼此显著相关，并且是摄入铅的函数。使用该技术评估了八种铅化合物，并将结果与作为参考化合物的醋酸铅相关联。在所研究的无机制剂中，碱式碳酸铅和金属铅的吸收存在12倍的差异，其余化合物给出中间值。从添加了7.5%玉米油的标准饮食中测定了四种有机化合物中铅的吸收情况。铅苯二甲酸酯的吸收程度与醋酸铅相同，但辛酸铅、环烷酸铅和烯丙基磺酸钠的吸收较少。将玉米油添加到饮食中最终浓度达到7.5%可提高醋酸铅的吸收。
