蛋白酶体的免疫功能。
Immunological functions of the proteasome.
作者信息
Niedermann G
机构信息
Max Planck Institute of Immunobiology, Stübeweg 51, 79108 Freiburg, Germany.
出版信息
Curr Top Microbiol Immunol. 2002;268:91-136. doi: 10.1007/978-3-642-59414-4_5.
PMID:12083010
Abstract
Proteasomes are highly abundant cytosolic and nuclear protease complexes that degrade most intracellular proteins in higher eukaryotes and appear to play a major role in the cytosolic steps of MHC class I antigen processing. This review summarizes the knowledge of the role of proteasomes in antigen processing and the impact of proteasomal proteolysis on T cell-mediated immunity.
摘要
蛋白酶体是高度丰富的胞质和核蛋白酶复合物，可降解高等真核生物中的大多数细胞内蛋白质，并且似乎在MHC I类抗原加工的胞质步骤中起主要作用。本综述总结了关于蛋白酶体在抗原加工中的作用以及蛋白酶体蛋白水解对T细胞介导的免疫的影响的知识。
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