免疫蛋白酶体亚基在人胸腺中的表达模式。
Expression pattern of immunoproteasome subunits in human thymus.
机构信息
Department of Pathology, Hallym University College of Medicine, Chuncheon 200-702, Korea.
出版信息
Immune Netw. 2009 Dec;9(6):285-8. doi: 10.4110/in.2009.9.6.285. Epub 2009 Dec 31.
Abstract
The expression pattern of immunoproteasomes in human thymus has not been analyzed but may have important consequences during thymic selection. Here we examined the expression patterns of immunoproteasome subunits in fetal and adult thymic tissues by immunohistochemistry and found that all three subunits are expressed in both cortical and medullary stromal cells. These data suggest that thymic selection in human can be affected by peptide repertoires generated by immunoproteasomes.
摘要
免疫蛋白酶体在人类胸腺中的表达模式尚未进行分析，但在胸腺选择过程中可能具有重要意义。本文通过免疫组织化学检测了免疫蛋白酶体亚基在胎儿和成人胸腺组织中的表达模式，发现所有三个亚基均在皮质和髓质基质细胞中表达。这些数据表明，人类的胸腺选择可能受到免疫蛋白酶体产生的肽库的影响。
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