蛋白酶体在其“朋友”的大量帮助下得以运转。

Proteasomes get by with lots of help from their friends.

作者信息

Yewdell Jonathan W, Princiotta Michael F

机构信息

Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 208920 USA.

出版信息

Immunity. 2004 Apr;20(4):362-3. doi: 10.1016/s1074-7613(04)00086-x.

DOI:10.1016/s1074-7613(04)00086-x

PMID:15084265

Abstract

Proteasomes can't do it all. It was previously known that aminopeptidases frequently degrade proteasome-generated peptides. Now it appears that another protease, tripeptidyl peptidase II (TPP II), plays a critical role in cleaving proteasomal produced peptides into shorter peptides that can then be degraded by aminopeptidases.

摘要

蛋白酶体无法独自完成所有任务。此前已知氨基肽酶常常会降解蛋白酶体产生的肽段。现在看来，另一种蛋白酶——三肽基肽酶II（TPP II），在将蛋白酶体产生的肽段切割成更短的肽段过程中发挥着关键作用，这些短肽随后可被氨基肽酶降解。