Gingrich J R, Chauhan R D, Steiner M S
Department of Urology, University of Tennessee Medical Center, 956 Court Avenue, H216, Memphis, TN 38163, USA.
Curr Urol Rep. 2001 Jun;2(3):199-208. doi: 10.1007/s11934-001-0079-8.
Basic research continues to unravel the molecular complexity of normal and abnormal biologic processes. The development of means to affect the expression level of genes that promote or contribute to cellular transformation, invasion, and metastasis has spawned the concept of gene therapy. This relatively new field seeks to reverse or suspend the pathologic progression of a variety of diseases including the malignant transformation of prostatic epithelial cells. Initial clinical trials for prostate cancer have thus far shown gene therapy to be relatively safe, although definitive evidence of durable therapeutic efficacy remains to be demonstrated. In this article, recent preclinical research, current therapeutic strategies, and recent results of gene therapy clinical trials for the treatment of prostate cancer are reviewed.
基础研究不断揭示正常和异常生物学过程的分子复杂性。影响促进或导致细胞转化、侵袭和转移的基因表达水平的方法的发展催生了基因治疗的概念。这个相对较新的领域试图逆转或中止包括前列腺上皮细胞恶性转化在内的多种疾病的病理进程。前列腺癌的初步临床试验迄今已表明基因治疗相对安全，尽管持久治疗效果的确切证据仍有待证实。本文综述了前列腺癌治疗的近期临床前研究、当前治疗策略以及基因治疗临床试验的最新结果。
