Malkowicz S B, Johnson J O
Department of Surgery, University of Pennsylvania, Philadelphia, USA.
Hematol Oncol Clin North Am. 1998 Jun;12(3):649-64. doi: 10.1016/s0889-8588(05)70013-7.
Prostate cancer remains one of the most significant challenges in clinical oncology, yet present therapies provide incomplete treatment in many cases. Innovative and practical gene therapy-based approaches will prove invaluable in filling the gaps that now exist in the treatment of localized and distant disease. Although multiple potential strategies have been developed, early clinical trials in prostate cancer gene therapy are now in the phase I/II stage of development. Novel preclinical and early clinical data should be considered optimistically, yet cautiously, as this field emerges from its infancy.
