Shen Min, Xiang Ping, Wu Hejian, Shen Baohua, Huang Zhongjie
Department of Forensic Chemistry, Institute of Forensic Sciences, Ministry of Justice, 200063 Shanghai, PR China.
Forensic Sci Int. 2002 Apr 18;126(2):153-61. doi: 10.1016/s0379-0738(02)00051-8.
The presence of therapeutic drugs and their metabolites in the hair of psychiatric patients was investigated using gas chromatography (GC)-mass spectroscopy (MS)-electron ionization (EI) and GC-MS-chemical ionization (CI). In hair samples tested from 35 subjects, carbamazepine, amitriptyline, doxepin, trihexyphenidyl, chlorpromazine, chlorprothixene, trifluoperazine, clozapine and haloperidol were detected, with maximal concentrations of 22.5, 57.7, 183.3, 15.6, 68.2, 30.0, 36.8, 59.2 and 20.1 ng/mg of hair sample, respectively. Chlorpromazine and clozapine concentrations in the hair were found to be dependent on the dosage used and their correlation coefficients were 0.8047 (P<0.001, n=16) and 0.7097 (P<0.001, n=16), respectively. Segmental analysis demonstrated that there was a correlation between the history of subject's drug exposure and the distribution of drug along the hair shaft. Our results also show that drug analysis in hair may provide useful information about drug treatment and the history of usage, and that drugs can be detected in normally kept hair for at least 16 months after intake.
采用气相色谱（GC）-质谱（MS）-电子电离（EI）和GC-MS-化学电离（CI）技术，对精神病患者头发中治疗药物及其代谢物的存在情况进行了研究。在对35名受试者的头发样本进行检测时，检测到了卡马西平、阿米替林、多塞平、苯海索、氯丙嗪、氯普噻吨、三氟拉嗪、氯氮平和氟哌啶醇，头发样本中的最大浓度分别为22.5、57.7、183.3、15.6、68.2、30.0、36.8、59.2和20.1 ng/mg。发现头发中的氯丙嗪和氯氮平浓度取决于所用剂量，其相关系数分别为0.8047（P<0.001，n = 16）和0.7097（P<0.001，n = 16）。分段分析表明，受试者的药物接触史与药物沿毛干的分布之间存在相关性。我们的研究结果还表明，头发中的药物分析可以提供有关药物治疗和用药史的有用信息，并且在摄入药物后至少16个月内，可以在正常保存的头发中检测到药物。
