Moody Terry W, Tuthill Cynthia, Badamchian Mahnaz, Goldstein Allan L
Cell and Cancer Biology Branch, National Cancer Institute, 9610 Medical Center Drive, Building KWC, Rockville, MD 20850, USA.
Peptides. 2002 May;23(5):1011-4. doi: 10.1016/s0196-9781(02)00025-6.
The effects of thymosin alpha1 (Talpha1) on mammary carcinogenesis was investigated in Fisher rats. Mammary carcinomas were observed 3 months after N-nitrosomethylurea (NMU) injection (10mg, i.p.) into Fisher rats. Daily administration of Talpha1 (10 microg, s.c.) reduced mammary carcinoma incidence and prolonged survival time. Animals treated with exogenous Talpha1 had a significantly greater blood white cell density than control Fisher rats. These results suggest that Talpha1 prevents mammary carcinoma incidence as a result of stimulation of the immune system.
在费希尔大鼠中研究了胸腺肽α1（Tα1）对乳腺癌发生的影响。向费希尔大鼠腹腔注射10毫克N-亚硝基甲基脲（NMU）3个月后观察到乳腺癌。每天皮下注射Tα1（10微克）可降低乳腺癌发病率并延长存活时间。接受外源性Tα1治疗的动物的血液白细胞密度明显高于对照费希尔大鼠。这些结果表明，Tα1通过刺激免疫系统预防乳腺癌的发生。
