Moody Terry W
Department of Health and Human Services, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Ann N Y Acad Sci. 2007 Sep;1112:297-304. doi: 10.1196/annals.1415.040. Epub 2007 Jun 13.
The ability of thymosin alpha1 (Talpha1) to prevent lung and breast cancer was investigated. Lung adenomas developed in A/J mice injected with carcinogens, such as urethane. The lung adenoma number was reduced by 15-45% if animals were daily treated subcutaneously (s.c.) with Talpha1 (0.4 mg/kg). Talpha1 (1 microM) directly inhibited the growth of mouse lung cell lines. These results suggest that Talpha1 may prevent mouse lung carcinogenesis because it directly inhibits the growth of lung cancer cells. Talpha1 prevented mammary carcinogenesis in two animal models. In the Fisher rat, an animal model of mammary cancer that is estrogen receptor dependent, tumors were initiated by the injection of N-methylurea (NMU). The rat survival was significantly increased by the daily injection of Talpha1. In the SV40T antigen mouse, a transgenic female mouse that spontaneously gets mammary cancer in an estrogen receptor-independent manner, survival was increased and tumor burden was significantly decreased by daily injection of Talpha1. These results indicate that Talpha1 is a chemopreventive agent in animal models for lung and breast carcinogenesis.
研究了胸腺肽α1（Tα1）预防肺癌和乳腺癌的能力。在注射致癌物（如氨基甲酸乙酯）的A/J小鼠中会发生肺腺瘤。如果动物每天皮下注射（s.c.）Tα1（0.4mg/kg），肺腺瘤数量会减少15 - 45%。Tα1（1μM）直接抑制小鼠肺癌细胞系的生长。这些结果表明，Tα1可能预防小鼠肺癌发生，因为它直接抑制肺癌细胞的生长。Tα1在两种动物模型中预防了乳腺癌发生。在费希尔大鼠（一种雌激素受体依赖性乳腺癌动物模型）中，通过注射N - 甲基脲（NMU）引发肿瘤。每天注射Tα1可显著提高大鼠存活率。在SV40T抗原小鼠（一种以雌激素受体非依赖性方式自发发生乳腺癌的转基因雌性小鼠）中，每天注射Tα1可提高存活率并显著降低肿瘤负荷。这些结果表明，Tα1在肺癌和乳腺癌发生的动物模型中是一种化学预防剂。
