Ohayon M M, Priest R G, Zulley J, Smirne S, Paiva T
Stanford Sleep Epidemiology Research Center, School of Medicine, Stanford University, CA 94305, USA.
Neurology. 2002 Jun 25;58(12):1826-33. doi: 10.1212/wnl.58.12.1826.
To determine the prevalence of narcolepsy in the general population of five European countries (target population 205,890,882 inhabitants).
Overall, 18,980 randomly selected subjects were interviewed (participation rate 80.4%). These subjects were representative of the general population of the UK, Germany, Italy, Portugal, and Spain. They were interviewed by telephone using the Sleep-EVAL expert system, which provided narcolepsy diagnosis according to the International Classification of Sleep Disorders (ICSD).
Excessive daytime sleepiness was reported by 15% of the sample, with a higher prevalence in the UK and Germany. Napping two times or more in the same day was reported by 1.6% of the sample, with a significantly higher rate in Germany. Cataplexy (episodes of loss of muscle function related to a strong emotion), a cardinal symptom of narcolepsy, was found in 1.6% of the sample. An ICSD narcolepsy diagnosis was found in 0.047% of the sample: The narcolepsy was severe for 0.026% of the sample and moderate in 0.021%.
This is the first epidemiologic study that estimates the prevalence of narcolepsy in the general population of these five European countries. The disorder affects 47 individuals/100,000 inhabitants.
确定五个欧洲国家普通人群中发作性睡病的患病率（目标人群为2.05890882亿居民）。
总体而言，对18980名随机选取的受试者进行了访谈（参与率为80.4%）。这些受试者代表了英国、德国、意大利、葡萄牙和西班牙的普通人群。通过电话使用Sleep-EVAL专家系统对他们进行访谈，该系统根据《国际睡眠障碍分类》（ICSD）提供发作性睡病诊断。
15%的样本报告有日间过度嗜睡，在英国和德国患病率更高。1.6%的样本报告同一天午睡两次或更多次，在德国这一比例显著更高。猝倒（与强烈情绪相关的肌肉功能丧失发作）是发作性睡病的主要症状，在1.6%的样本中被发现。在0.047%的样本中发现了ICSD发作性睡病诊断：0.02%的样本为重度发作性睡病，0.021%为中度。
这是第一项估算这五个欧洲国家普通人群中发作性睡病患病率的流行病学研究。该疾病影响47人/10万居民。
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