Bu X, Bernstein L, Brynes R K
Department of Pathology, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA.
Br J Cancer. 2002 Jul 1;87(1):28-30. doi: 10.1038/sj.bjc.6600362.
Synovial sarcoma shows a characteristic t(X;18) translocation but not the expected female predominance in incidence. We speculate that, among females, one X-chromosome is inactivated and that only the translocation to an active X-chromosome leads to development of synovial sarcoma. Population-based cancer registry data from the SEER program support this hypothesis.
滑膜肉瘤显示出特征性的t(X;18)易位,但在发病率上并无预期的女性优势。我们推测,在女性中,一条X染色体失活,只有易位到活跃的X染色体才会导致滑膜肉瘤的发生。美国国立癌症研究所监测、流行病学和最终结果(SEER)项目基于人群的癌症登记数据支持这一假说。