Dal Cin P, Rao U, Jani-Sait S, Karakousis C, Sandberg A A
Cancer Center of Southwest Biomedical Research Institute, Scottsdale, Arizona.
Mod Pathol. 1992 Jul;5(4):357-62.
It has been established that nonrandom chromosome rearrangements are characteristic of specific types of neoplasia. We present six new cases of sarcoma that had in common the same chromosome abnormality, i.e., a balanced translocation between chromosomes X and 18, t(X;18)(p11.2;q11.2), and evaluate the 15 cases with this translocation in the literature. The histological diagnosis was synovial sarcoma in 19 cases and malignant fibrous histiocytoma and fibrosarcoma in the remaining two tumors, respectively. The translocation was found in tumors of both the biphasic and monophasic types, as well as in poorly differentiated synovial sarcoma. The two nonsynovial sarcomas with the t(X;18) were described as spindle cell tumors but failed to show the presence of cytokeratins by immunohistochemical stains. Even with the numerous variabilities on which this test depends, the cytogenetic analysis holds great promise as a tool for the diagnosis of synovial sarcoma.
已经确定非随机染色体重排是特定类型肿瘤形成的特征。我们报告了6例新的肉瘤病例，它们都有相同的染色体异常，即X染色体和18号染色体之间的平衡易位，t(X;18)(p11.2;q11.2)，并对文献中15例有这种易位的病例进行了评估。组织学诊断为19例滑膜肉瘤，其余2例肿瘤分别为恶性纤维组织细胞瘤和纤维肉瘤。在双相型和单相型肿瘤以及低分化滑膜肉瘤中均发现了这种易位。这两例伴有t(X;18)的非滑膜肉瘤被描述为梭形细胞瘤，但免疫组化染色未显示细胞角蛋白的存在。尽管该检测依赖的因素众多且存在变异性，但细胞遗传学分析作为诊断滑膜肉瘤的工具仍具有很大的前景。
