Akhmedkhanov A, Toniolo P, Zeleniuch-Jacquotte A, Koenig K L, Shore R E
Department of Obstetrics and Gynecology, New York University School of Medicine, 550 First Avenue, NBV-9E2, New York, NY 10016, USA.
Br J Cancer. 2002 Jul 1;87(1):49-53. doi: 10.1038/sj.bjc.6600370.
The association between aspirin use and lung cancer risk in women was examined in a case-control study nested in the New York University Women's Health Study, a large cohort in New York. Case subjects were all the 81 incident lung cancer cases who had provided information about aspirin use at enrollment and during the 1994-1996 follow up. Ten controls per case were randomly selected from among study participants who matched a case by age, menopausal status, and dates of enrollment and follow-up. Relative to no aspirin use, the odds ratio for lung cancer (all histological sub-types combined) among subjects who reported aspirin use three or more times per week for at least 6 months was 0.66 (95% confidence interval 0.34-1.28), after adjustment for smoking and education. A stronger inverse association was observed in analyses restricted to non-small cell lung cancer (adjusted odds ratio 0.39, 95% confidence interval 0.16-0.96). These results suggest that regular aspirin use might be inversely associated with risk of lung cancer in women, particularly the non-small cell sub-type.
在纽约大学女性健康研究（纽约的一个大型队列研究）中开展的一项巢式病例对照研究，考察了女性使用阿司匹林与肺癌风险之间的关联。病例组为所有81例新发肺癌病例，这些病例在入组时以及1994 - 1996年随访期间提供了阿司匹林使用情况的信息。按照年龄、绝经状态、入组日期和随访日期与病例匹配的原则，从研究参与者中为每个病例随机选取10名对照。在对吸烟和教育程度进行调整后，相对于未使用阿司匹林，每周至少服用3次阿司匹林且持续至少6个月的受试者患肺癌（所有组织学亚型合并）的比值比为0.66（95%置信区间0.34 - 1.28）。在仅限于非小细胞肺癌的分析中观察到更强的负相关（调整后的比值比为0.39，95%置信区间0.16 - 0.96）。这些结果表明，规律使用阿司匹林可能与女性肺癌风险呈负相关，尤其是非小细胞肺癌亚型。
