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阿司匹林使用与癌症风险的关联：观察性研究的荟萃分析。

Associations between aspirin use and the risk of cancers: a meta-analysis of observational studies.

机构信息

Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.

Department of Nutriology, The People's Hospital of Henan Province, Zhengzhou, Henan, 450003, People's Republic of China.

出版信息

BMC Cancer. 2018 Mar 13;18(1):288. doi: 10.1186/s12885-018-4156-5.

DOI:10.1186/s12885-018-4156-5
PMID:29534696
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5851082/
Abstract

BACKGROUND

Epidemiological studies have clarified the potential associations between regular aspirin use and cancers. However, it remains controversial on whether aspirin use decreases the risk of cancers risks. Therefore, we conducted an updated meta-analysis to assess the associations between aspirin use and cancers.

METHODS

The PubMed, Embase, and Web of Science databases were systematically searched up to March 2017 to identify relevant studies. Relative risks (RRs) with 95% confidence intervals (CIs) were used to assess the strength of associations.

RESULTS

A total of 218 studies with 309 reports were eligible for this meta-analysis. Aspirin use was associated with a significant decrease in the risk of overall cancer (RR = 0.89, 95% CI: 0.87-0.91), and gastric (RR = 0.75, 95% CI: 0.65-0.86), esophageal (RR = 0.75, 95% CI: 0.62-0.89), colorectal (RR = 0.79, 95% CI: 0.74-0.85), pancreatic (RR = 0.80, 95% CI: 0.68-0.93), ovarian (RR = 0.89, 95% CI: 0.83-0.95), endometrial (RR = 0.92, 95% CI: 0.85-0.99), breast (RR = 0.92, 95% CI: 0.88-0.96), and prostate (RR = 0.94, 95% CI: 0.90-0.99) cancers, as well as small intestine neuroendocrine tumors (RR = 0.17, 95% CI: 0.05-0.58).

CONCLUSIONS

These findings suggest that aspirin use is associated with a reduced risk of gastric, esophageal, colorectal, pancreatic, ovarian, endometrial, breast, and prostate cancers, and small intestine neuroendocrine tumors.

摘要

背景

流行病学研究已经明确了常规使用阿司匹林与癌症之间的潜在关联。然而，阿司匹林的使用是否降低癌症风险仍存在争议。因此，我们进行了一项更新的荟萃分析，以评估阿司匹林的使用与癌症之间的关联。

方法

系统检索了 PubMed、Embase 和 Web of Science 数据库，以确定相关研究。使用相对风险（RR）及其 95%置信区间（CI）来评估关联的强度。

结果

共有 218 项研究和 309 项报告符合纳入标准。荟萃分析结果显示，阿司匹林的使用与总体癌症（RR=0.89，95%CI：0.87-0.91）、胃癌（RR=0.75，95%CI：0.65-0.86）、食管癌（RR=0.75，95%CI：0.62-0.89）、结直肠癌（RR=0.79，95%CI：0.74-0.85）、胰腺癌（RR=0.80，95%CI：0.68-0.93）、卵巢癌（RR=0.89，95%CI：0.83-0.95）、子宫内膜癌（RR=0.92，95%CI：0.85-0.99）、乳腺癌（RR=0.92，95%CI：0.88-0.96）和前列腺癌（RR=0.94，95%CI：0.90-0.99）以及小肠神经内分泌肿瘤（RR=0.17，95%CI：0.05-0.58）的风险降低相关。

结论

这些发现表明，阿司匹林的使用与胃癌、食管癌、结直肠癌、胰腺癌、卵巢癌、子宫内膜癌、乳腺癌和前列腺癌以及小肠神经内分泌肿瘤的风险降低相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b59e/5851082/04b9d23b9385/12885_2018_4156_Fig19_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b59e/5851082/7e966bd68649/12885_2018_4156_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b59e/5851082/7e966bd68649/12885_2018_4156_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b59e/5851082/c1d5978df17f/12885_2018_4156_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b59e/5851082/d9b1e18faa04/12885_2018_4156_Fig3_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b59e/5851082/791a9d3443da/12885_2018_4156_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b59e/5851082/179b85843f7d/12885_2018_4156_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b59e/5851082/4abab06ce308/12885_2018_4156_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b59e/5851082/b6a60cc9d1ef/12885_2018_4156_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b59e/5851082/bc43c9b358c4/12885_2018_4156_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b59e/5851082/613800c82cd7/12885_2018_4156_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b59e/5851082/3817baf93062/12885_2018_4156_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b59e/5851082/e1db61f0124b/12885_2018_4156_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b59e/5851082/3a9971d2c98d/12885_2018_4156_Fig13_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b59e/5851082/c6bcc706dc2a/12885_2018_4156_Fig14_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b59e/5851082/14524567782d/12885_2018_4156_Fig15_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b59e/5851082/4022378f66ab/12885_2018_4156_Fig16_HTML.jpg
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