Milner J A, Prior R L, Visek W J
Proc Soc Exp Biol Med. 1975 Nov;150(2):282-8. doi: 10.3181/00379727-150-39020.
Dietary arginine deficiency in rats causes significant increases in urinary excretion of urea, citric acid and orotic acid independently of feed intake. Urea excretion during arginine deficiency depends upon the diet, sex, age, and species. Thus urea excretion has limitations as an indicator of arginine availability. Although elevated urinary citric acid during arginine deficiency is more consistently observed, it may be influenced by citric acid in natural dietary ingredients. Orotic acid excretion, however, appears to be a reliable indicator of available dietary arginine based upon studies in rats, mice, hamsters, guinea pigs, rabbits, and dogs.
大鼠饮食中精氨酸缺乏会导致尿素、柠檬酸和乳清酸的尿排泄量显著增加，且与采食量无关。精氨酸缺乏期间的尿素排泄取决于饮食、性别、年龄和物种。因此，尿素排泄作为精氨酸可利用性的指标存在局限性。虽然在精氨酸缺乏期间尿柠檬酸升高的情况更一致地被观察到，但它可能受天然饮食成分中柠檬酸的影响。然而，基于对大鼠、小鼠、仓鼠、豚鼠、兔子和狗的研究，乳清酸排泄似乎是饮食中可利用精氨酸的可靠指标。
