Wishart T B, Walls E K
Physiol Behav. 1975 Sep;15(3):377-9. doi: 10.1016/0031-9384(75)90107-9.
Rats received large, bilateral lesions of the ventromedial hypothalamus. Water or saline intakes, urine outputs and body temperatures were observed for up to 24 hr after surgery. Fifty percent of the operated animals drank excessively and died within 4-6 hr when permitted access to water. Urine outputs were low and symptoms of water intoxication were evident. When allowed access to saline, outputs rose and the number of animals which survived increased as the saline concentration increased. Body temperatures approached 40 degrees C during drinking, but did not differ from operated animals which refused to drink. It was concluded that the deposition of metallic ions strongly stimulates a hypothalamic drinking system which results in overhydration and water intoxication death.
给大鼠双侧腹内侧下丘脑造成大面积损伤。术后观察长达24小时的水或盐水摄入量、尿量及体温。50%的手术动物在能获取水时会过度饮水，并在4 - 6小时内死亡。尿量少，水中毒症状明显。当给予盐水时，尿量增加，随着盐水浓度升高，存活动物数量增多。饮水时体温接近40摄氏度，但与拒绝饮水的手术动物无差异。得出的结论是，金属离子的沉积强烈刺激下丘脑饮水系统，导致水摄入过多和水中毒死亡。
