Decipinin A以及Decipienolides A和B：来自粪生真菌Podospora decipiens的新型生物活性代谢产物。

Decipinin A and decipienolides A and B: new bioactive metabolites from the coprophilous fungus Podospora decipiens.

作者信息

Che Yongsheng, Gloer James B, Koster Brenda, Malloch David

机构信息

Department of Chemistry, University of Iowa, Iowa City, Iowa, 52242, USA.

出版信息

J Nat Prod. 2002 Jun;65(6):916-9. doi: 10.1021/np010575p.

DOI:10.1021/np010575p

PMID:12088438

Abstract

Decipinin A (1), a new compound with antifungal and antibacterial activity, has been isolated from liquid cultures of the coprophilous fungus Podospora decipiens (JS 270). Two new tetracyclic sesquiterpene lactones, decipienolides A (2) and B (3), were also obtained from this isolate as an inseparable mixture of epimers that showed antibacterial activity. The structures of 1-3 were elucidated by analysis of 1D and 2D NMR data, aided by chemical shift comparisons to related compounds.

摘要

从粪生真菌Podospora decipiens（JS 270）的液体培养物中分离出了具有抗真菌和抗菌活性的新化合物Decipinin A（1）。还从该分离物中获得了两种新的四环倍半萜内酯，Decipienolides A（2）和B（3），它们是具有抗菌活性的差向异构体的不可分离混合物。通过分析一维和二维核磁共振数据，并与相关化合物进行化学位移比较，阐明了1-3的结构。