Deyrup Stephen T, Swenson Dale C, Gloer James B, Wicklow Donald T
Department of Chemistry, University of Iowa, Iowa City, IA 52242, USA.
J Nat Prod. 2006 Apr;69(4):608-11. doi: 10.1021/np050460b.
Three new caryophyllene-type sesquiterpene alcohols, 6-hydroxypunctaporonin E (1), 6-hydroxypunctaporonin B (2), and 6-hydroxypunctaporonin A (3), have been isolated from cultures of the fungicolous fungus Pestalotiopsis disseminata. The structures of 1-3 were determined mainly by analysis of 1D and 2D NMR data. The structure and absolute configuration of 6-hydroxypunctaporonin E (1) was confirmed through X-ray crystallographic analysis of its mono-bromobenzoate derivative. Compounds 1 and 2 showed activity against Gram-positive bacteria.
从真菌寄生真菌扩散拟盘多毛孢（Pestalotiopsis disseminata）的培养物中分离出三种新的石竹烯型倍半萜醇，即6-羟基点孢多孔菌素E（1）、6-羟基点孢多孔菌素B（2）和6-羟基点孢多孔菌素A（3）。1-3的结构主要通过一维和二维核磁共振数据的分析来确定。通过对其单溴苯甲酸酯衍生物的X射线晶体学分析，确定了6-羟基点孢多孔菌素E（1）的结构和绝对构型。化合物1和2对革兰氏阳性菌显示出活性。
