来自散斑拟盘多毛孢菌的一种真菌寄生分离株的石竹烯倍半萜类化合物。

Caryophyllene sesquiterpenoids from a fungicolous isolate of Pestalotiopsis disseminata.

作者信息

Deyrup Stephen T, Swenson Dale C, Gloer James B, Wicklow Donald T

机构信息

Department of Chemistry, University of Iowa, Iowa City, IA 52242, USA.

出版信息

J Nat Prod. 2006 Apr;69(4):608-11. doi: 10.1021/np050460b.

DOI:10.1021/np050460b

PMID:16643036

Abstract

Three new caryophyllene-type sesquiterpene alcohols, 6-hydroxypunctaporonin E (1), 6-hydroxypunctaporonin B (2), and 6-hydroxypunctaporonin A (3), have been isolated from cultures of the fungicolous fungus Pestalotiopsis disseminata. The structures of 1-3 were determined mainly by analysis of 1D and 2D NMR data. The structure and absolute configuration of 6-hydroxypunctaporonin E (1) was confirmed through X-ray crystallographic analysis of its mono-bromobenzoate derivative. Compounds 1 and 2 showed activity against Gram-positive bacteria.

摘要

从真菌寄生真菌扩散拟盘多毛孢（Pestalotiopsis disseminata）的培养物中分离出三种新的石竹烯型倍半萜醇，即6-羟基点孢多孔菌素E（1）、6-羟基点孢多孔菌素B（2）和6-羟基点孢多孔菌素A（3）。1-3的结构主要通过一维和二维核磁共振数据的分析来确定。通过对其单溴苯甲酸酯衍生物的X射线晶体学分析，确定了6-羟基点孢多孔菌素E（1）的结构和绝对构型。化合物1和2对革兰氏阳性菌显示出活性。