Possible genetic consequences of irradiation of tumors in childhood.

Dysgenic and radiation-induced types of genetic risks are evaluated for the progeny of persons who received childhood tumor therapy. The dysgenic risks may be quite high for certain types of tumors. The genetic defects of greatest concern following paternal irradiation are likely to be those caused by dominant mutations and unbalanced translocations, whereas chromosomal trisomies may be most important following maternal irradiation. Ways of alleviating these risks are discussed.