Molmeret Maëlle, Abu Kwaik Yousef
Dept of Microbiology and Immunology, University of Kentucky Chandler Medical Center, Lexington, KY 40536-0084, USA.
Trends Microbiol. 2002 Jun;10(6):258-60. doi: 10.1016/s0966-842x(02)02359-4.
In recent years, tremendous progress has been made in unraveling the elegant mechanisms by which intracellular pathogens invade host cells and establish intracellular infections. By contrast, our knowledge of the mechanisms of host cell cytolysis and the egress of intracellular pathogens is still in its infancy. Temporal pore-formation-mediated lysis of the host and exit by Legionella pneumophila and Leishmania could provide a new model of egress for other intracellular pathogens, many of which exhibit pore-forming or cytolysin activity
近年来，在揭示细胞内病原体侵入宿主细胞并建立细胞内感染的精妙机制方面已经取得了巨大进展。相比之下，我们对宿主细胞溶解机制以及细胞内病原体逸出的了解仍处于起步阶段。嗜肺军团菌和利什曼原虫通过瞬时孔形成介导的宿主细胞溶解和逸出，可能为其他细胞内病原体提供一种新的逸出模式，其中许多病原体都具有孔形成或溶细胞素活性
