• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Role for RpoS but not RelA of Legionella pneumophila in modulation of phagosome biogenesis and adaptation to the phagosomal microenvironment.嗜肺军团菌的RpoS而非RelA在调节吞噬体生物发生及适应吞噬体微环境中的作用。
Infect Immun. 2006 May;74(5):3021-6. doi: 10.1128/IAI.74.5.3021-3026.2006.
2
Role for the Ankyrin eukaryotic-like genes of Legionella pneumophila in parasitism of protozoan hosts and human macrophages.嗜肺军团菌锚蛋白类真核基因在原生动物宿主和人类巨噬细胞寄生中的作用。
Environ Microbiol. 2008 Jun;10(6):1460-74. doi: 10.1111/j.1462-2920.2007.01560.x. Epub 2008 Feb 14.
3
Characterization of a Legionella pneumophila relA insertion mutant and toles of RelA and RpoS in virulence gene expression.嗜肺军团菌relA插入突变体的特性以及RelA和RpoS在毒力基因表达中的作用
J Bacteriol. 2002 Jan;184(1):67-75. doi: 10.1128/JB.184.1.67-75.2002.
4
Disruption of the phagosomal membrane and egress of Legionella pneumophila into the cytoplasm during the last stages of intracellular infection of macrophages and Acanthamoeba polyphaga.在巨噬细胞和多噬棘阿米巴细胞内感染的最后阶段，嗜肺军团菌的吞噬体膜破裂并逸出到细胞质中。
Infect Immun. 2004 Jul;72(7):4040-51. doi: 10.1128/IAI.72.7.4040-4051.2004.
5
Activation of caspase-3 by the Dot/Icm virulence system is essential for arrested biogenesis of the Legionella-containing phagosome.Dot/Icm 毒力系统对caspase-3的激活对于含军团菌吞噬体生物合成的停滞至关重要。
Cell Microbiol. 2004 Jan;6(1):33-48. doi: 10.1046/j.1462-5822.2003.00335.x.
6
RpoS co-operates with other factors to induce Legionella pneumophila virulence in the stationary phase.RpoS与其他因子协同作用，在稳定期诱导嗜肺军团菌的毒力。
Mol Microbiol. 2001 Jun;40(5):1201-14. doi: 10.1046/j.1365-2958.2001.02465.x.
7
SigmaS controls multiple pathways associated with intracellular multiplication of Legionella pneumophila.西格玛因子S控制与嗜肺军团菌细胞内增殖相关的多条途径。
J Bacteriol. 2009 Apr;191(8):2461-73. doi: 10.1128/JB.01578-08. Epub 2009 Feb 13.
8
A Dot/Icm-translocated ankyrin protein of Legionella pneumophila is required for intracellular proliferation within human macrophages and protozoa.嗜肺军团菌的一种Dot/Icm易位锚蛋白是其在人类巨噬细胞和原生动物细胞内增殖所必需的。
Mol Microbiol. 2008 Nov;70(4):908-23. doi: 10.1111/j.1365-2958.2008.06453.x. Epub 2008 Sep 22.
9
The Legionella pneumophila response regulator LqsR promotes host cell interactions as an element of the virulence regulatory network controlled by RpoS and LetA.嗜肺军团菌反应调节因子LqsR作为由RpoS和LetA控制的毒力调节网络的一个组成部分，促进宿主细胞相互作用。
Cell Microbiol. 2007 Dec;9(12):2903-20. doi: 10.1111/j.1462-5822.2007.01005.x. Epub 2007 Jul 5.
10
The Legionella pneumophila rpoS gene is required for growth within Acanthamoeba castellanii.嗜肺军团菌的rpoS基因是嗜肺军团菌在卡氏棘阿米巴中生长所必需的。
J Bacteriol. 1999 Aug;181(16):4879-89. doi: 10.1128/JB.181.16.4879-4889.1999.

引用本文的文献

1
Transcription factors DksA and PsrA are synergistic contributors to virulence in protozoa.转录因子DksA和PsrA是原生动物毒力的协同促成因素。
Microbiology (Reading). 2025 Apr;171(4). doi: 10.1099/mic.0.001551.
2
Overview of the Clinical and Molecular Features of Legionella Pneumophila: Focus on Novel Surveillance and Diagnostic Strategies.嗜肺军团菌的临床与分子特征概述：聚焦新型监测与诊断策略
Antibiotics (Basel). 2022 Mar 9;11(3):370. doi: 10.3390/antibiotics11030370.
3
Transcriptomic Changes of During Intracellular Growth in a Salmon Macrophage-Like Cell Line.在三文鱼巨噬细胞样细胞系中的细胞内生长过程中的转录组变化。
Front Cell Infect Microbiol. 2020 Jan 9;9:426. doi: 10.3389/fcimb.2019.00426. eCollection 2019.
4
A Two-Component System That Modulates Cyclic di-GMP Metabolism Promotes Legionella pneumophila Differentiation and Viability in Low-Nutrient Conditions.一种调节环二鸟苷酸代谢的双组分系统促进军团菌在低营养条件下的分化和存活。
J Bacteriol. 2019 Aug 8;201(17). doi: 10.1128/JB.00253-19. Print 2019 Sep 1.
5
Antibiotic Killing of Diversely Generated Populations of Nonreplicating Bacteria.抗生素对非复制细菌的多种生成群体的杀灭作用。
Antimicrob Agents Chemother. 2019 Jun 24;63(7). doi: 10.1128/AAC.02360-18. Print 2019 Jul.
6
The many forms of a pleomorphic bacterial pathogen-the developmental network of Legionella pneumophila.多形性细菌病原体的多种形态——嗜肺军团菌的发育网络
Front Microbiol. 2014 Dec 22;5:670. doi: 10.3389/fmicb.2014.00670. eCollection 2014.
7
A regulatory feedback loop between RpoS and SpoT supports the survival of Legionella pneumophila in water.RpoS和SpoT之间的调节反馈回路支持嗜肺军团菌在水中的存活。
Appl Environ Microbiol. 2015 Feb;81(3):918-28. doi: 10.1128/AEM.03132-14. Epub 2014 Nov 21.
8
Cellular microbiology and molecular ecology of Legionella-amoeba interaction.军团菌-变形虫相互作用的细胞微生物学和分子生态学。
Virulence. 2013 May 15;4(4):307-14. doi: 10.4161/viru.24290. Epub 2013 Mar 27.
9
Small Regulatory RNA and Legionella pneumophila.小调控 RNA 和嗜肺军团菌。
Front Microbiol. 2011 May 6;2:98. doi: 10.3389/fmicb.2011.00098. eCollection 2011.
10
Legionella Pneumophila Transcriptome during Intracellular Multiplication in Human Macrophages.嗜肺军团菌在人类巨噬细胞内增殖过程中的转录组
Front Microbiol. 2011 Apr 4;2:60. doi: 10.3389/fmicb.2011.00060. eCollection 2011.

本文引用的文献

1
The Francisella tularensis pathogenicity island protein IglC and its regulator MglA are essential for modulating phagosome biogenesis and subsequent bacterial escape into the cytoplasm.土拉弗朗西斯菌致病岛蛋白IglC及其调节因子MglA对于调节吞噬体生物发生以及随后细菌逃逸到细胞质中至关重要。
Cell Microbiol. 2005 Jul;7(7):969-79. doi: 10.1111/j.1462-5822.2005.00526.x.
2
Modulation of biogenesis of the Francisella tularensis subsp. novicida-containing phagosome in quiescent human macrophages and its maturation into a phagolysosome upon activation by IFN-gamma.土拉弗朗西斯菌新凶手亚种含吞噬体在静止人巨噬细胞中的生物合成调控及其在γ干扰素激活后成熟为吞噬溶酶体的过程。
Cell Microbiol. 2005 Jul;7(7):957-67. doi: 10.1111/j.1462-5822.2005.00529.x.
3
Maturation of the Legionella pneumophila-containing phagosome into a phagolysosome within gamma interferon-activated macrophages.嗜肺军团菌吞噬体在γ干扰素激活的巨噬细胞内成熟为吞噬溶酶体。
Infect Immun. 2005 May;73(5):3166-71. doi: 10.1128/IAI.73.5.3166-3171.2005.
4
Amoebae as training grounds for intracellular bacterial pathogens.变形虫作为细胞内细菌病原体的训练场。
Appl Environ Microbiol. 2005 Jan;71(1):20-8. doi: 10.1128/AEM.71.1.20-28.2005.
5
Differentiate to thrive: lessons from the Legionella pneumophila life cycle.分化以求生存：嗜肺军团菌生命周期的启示
Mol Microbiol. 2004 Jul;53(1):29-40. doi: 10.1111/j.1365-2958.2004.04129.x.
6
Disruption of the phagosomal membrane and egress of Legionella pneumophila into the cytoplasm during the last stages of intracellular infection of macrophages and Acanthamoeba polyphaga.在巨噬细胞和多噬棘阿米巴细胞内感染的最后阶段，嗜肺军团菌的吞噬体膜破裂并逸出到细胞质中。
Infect Immun. 2004 Jul;72(7):4040-51. doi: 10.1128/IAI.72.7.4040-4051.2004.
7
The LetE protein enhances expression of multiple LetA/LetS-dependent transmission traits by Legionella pneumophila.LetE蛋白增强了嗜肺军团菌多种LetA/LetS依赖性传播特性的表达。
Infect Immun. 2004 Jun;72(6):3284-93. doi: 10.1128/IAI.72.6.3284-3293.2004.
8
Cell biology of the intracellular infection by Legionella pneumophila.嗜肺军团菌细胞内感染的细胞生物学
Microbes Infect. 2004 Jan;6(1):129-39. doi: 10.1016/j.micinf.2003.11.004.
9
Activation of caspase-3 by the Dot/Icm virulence system is essential for arrested biogenesis of the Legionella-containing phagosome.Dot/Icm 毒力系统对caspase-3的激活对于含军团菌吞噬体生物合成的停滞至关重要。
Cell Microbiol. 2004 Jan;6(1):33-48. doi: 10.1046/j.1462-5822.2003.00335.x.
10
Macroautophagy is dispensable for intracellular replication of Legionella pneumophila in Dictyostelium discoideum.巨自噬对于嗜肺军团菌在盘基网柄菌中的细胞内复制并非必需。
Mol Microbiol. 2004 Jan;51(1):63-72. doi: 10.1046/j.1365-2958.2003.03826.x.

嗜肺军团菌的RpoS而非RelA在调节吞噬体生物发生及适应吞噬体微环境中的作用。

Role for RpoS but not RelA of Legionella pneumophila in modulation of phagosome biogenesis and adaptation to the phagosomal microenvironment.

作者信息

Abu-Zant Alaeddin, Asare Rexford, Graham James E, Abu Kwaik Yousef

机构信息

Department of Microbiology, University of Louisville College of Medicine, Louisville, KY 40292, USA.

出版信息

Infect Immun. 2006 May;74(5):3021-6. doi: 10.1128/IAI.74.5.3021-3026.2006.

DOI:10.1128/IAI.74.5.3021-3026.2006
PMID:16622243
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1459718/
Abstract

The induction of virulence traits by Legionella pneumophila at the post-exponential phase has been proposed to be triggered by the stringent response mediated by RelA, which triggers RpoS. We show that L. pneumophila rpoS but not relA is required for early intracellular survival and replication within human monocyte-derived macrophages and Acanthamoeba polyphaga. In addition, L. pneumophila rpoS but not relA is required for expression of the pore-forming activity. We provide evidence that RpoS plays a role in the modulation of phagosome biogenesis and in adaptation to the phagosomal microenvironment. Thus, there is no functional link between the stringent response and RpoS in the pathogenesis of L. pneumophila.

摘要

嗜肺军团菌在指数生长后期诱导毒力特性被认为是由RelA介导的严谨反应触发的，RelA会触发RpoS。我们发现，嗜肺军团菌的RpoS而非RelA是其在人单核细胞衍生巨噬细胞和多噬棘阿米巴中早期细胞内存活和复制所必需的。此外，嗜肺军团菌的RpoS而非RelA是形成孔道活性表达所必需的。我们提供的证据表明，RpoS在吞噬体生物发生的调节以及对吞噬体微环境的适应中发挥作用。因此，在嗜肺军团菌的发病机制中，严谨反应与RpoS之间不存在功能联系。