Lefrançois Leo, Masopust David
Division of Immunology, Department of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030-1319, USA.
Curr Opin Immunol. 2002 Aug;14(4):503-8. doi: 10.1016/s0952-7915(02)00360-6.
Immune responses to infection or effective vaccination generally result in the development of memory lymphocytes capable of mounting a rapid response to secondary infection. Since most infections initiate in non-lymphoid tissues, defense at these sites may be important for protection. Recent results suggest that a substantial portion of the T cell response to infection is focused in non-lymphoid tissues. Furthermore, anatomic localization appears to define phenotypic and functional heterogeneity among antigen-specific memory T cell populations.
对感染或有效疫苗接种的免疫反应通常会导致记忆淋巴细胞的产生，这些记忆淋巴细胞能够对二次感染迅速做出反应。由于大多数感染始于非淋巴组织，这些部位的防御对于保护可能很重要。最近的研究结果表明，T细胞对感染的反应很大一部分集中在非淋巴组织中。此外，解剖定位似乎决定了抗原特异性记忆T细胞群体之间的表型和功能异质性。
