Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Victoria 3010, Australia.
Curr Opin Immunol. 2013 Jun;25(3):329-33. doi: 10.1016/j.coi.2013.05.007. Epub 2013 Jun 5.
Antigen experienced or memory T cells make a critical contribution to immunity against infection. Many pathogens colonise non-lymphoid tissues and memory T cells in these compartments can deal with such localised infections. Emerging data show that there are at least two phenotypically distinct peripheral T cell subsets, one permanently resident and one recirculating between tissues and blood. A full appreciation of the T cells in the non-lymphoid memory pool and their relationship to those in the circulation is an important step in understanding how to generate and exploit effective peripheral immunity for the purpose of infection control.
有抗原经验或记忆的 T 细胞对感染免疫有重要贡献。许多病原体定殖于非淋巴组织，这些部位的记忆 T 细胞可以应对局部感染。新出现的数据表明，外周 T 细胞亚群至少有两种表型不同，一种是永久驻留的，另一种在组织和血液之间循环。充分了解非淋巴组织记忆库中的 T 细胞及其与循环中 T 细胞的关系，是理解如何为控制感染而产生和利用有效的外周免疫的重要步骤。
