Mäkelä Olli, Penttilä Pirkko, Kolehmainen Eila, Sukura Antti, Sankari Satu, Tulamo Riitta-Mari
Faculty of Veterinary Medicine, University of Helsinki, P.O. Box 57, FIN-00014 University of Helsinki, Helsinki, Finland.
Nucl Med Biol. 2002 Jul;29(5):593-8. doi: 10.1016/s0969-8051(02)00317-7.
Holmium-166 ferric hydroxide macroaggregate (Ho-166 FHMA) particles possess two important properties for radiosynovectomy; relatively short half-life of the radioisotope and appropriate carrier size. Both these minimize radioactive leakage from the treated joint. This study was conducted to assess the effects of Ho-166 FHMA on synovium and synovial fluid in rabbit knee joints. Whole-knee autoradiography was utilized to determine distribution of radioactivity after intra-articular Ho-166 FHMA injection. Intra-articular injection of Ho-166 FHMA resulted in focal acute radiation necrosis in synovial lining but no hyperplasia of synoviocytes. Later, subsynovial fibrosis became evident. White blood cell and total protein levels in the joint fluid were elevated because of intra-articular inflammation due to the acute effects of radiation. Whole knee autoradiograms showed uneven distribution of the radionuclide along the synovium and extraarticular leakage on the third day after treatment.
钬-166氢氧化铁大颗粒聚合体（Ho-166 FHMA）微粒具有放射性滑膜切除所需的两个重要特性；放射性同位素的半衰期相对较短且载体大小合适。这两者都能将治疗关节的放射性泄漏降至最低。本研究旨在评估Ho-166 FHMA对兔膝关节滑膜和滑液的影响。关节内注射Ho-166 FHMA后，利用全膝关节放射自显影术确定放射性分布。关节内注射Ho-166 FHMA导致滑膜衬里出现局灶性急性放射性坏死，但滑膜细胞无增生。随后，滑膜下纤维化变得明显。由于辐射的急性作用导致关节内炎症，关节液中的白细胞和总蛋白水平升高。全膝关节放射自显影片显示，治疗后第三天，放射性核素沿滑膜分布不均且有关节外渗漏。
