用165Dy氢氧化铁大颗粒进行实验性放射性滑膜切除术。
Experimental radiation synovectomy by 165Dy ferric hydroxide macroaggregate.
作者信息
Sledge C B, Noble J, Hnatowich D J, Kramer R, Shortkroff S
出版信息
Arthritis Rheum. 1977 Sep-Oct;20(7):1334-42. doi: 10.1002/art.1780200706.
PMID:911352
Abstract
The short half-life beta emitter 165Dy coprecipitated as a macroaggregate with ferric hydroxide (FHMA) has been shown to destroy knee synovium in the antigen-induced arthritic rabbit. Using 153Gd as a gamma tracer for leakage studies revealed that the leakage of this system from rabbit knee joints never exceeded 1.2% over 24 hours. This is such less than the leakage rates reported from any human studies or our rabbit studies using 198Au.
摘要
短半衰期β发射体165Dy与氢氧化铁（FHMA）共沉淀形成大聚集体，已证实在抗原诱导性关节炎兔中可破坏膝关节滑膜。使用153Gd作为γ示踪剂进行泄漏研究表明，该系统从兔膝关节的泄漏在24小时内从未超过1.2%。这远低于任何人体研究或我们使用198Au的兔研究报告的泄漏率。
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