氢氧化铁大聚集体（FHMA）的体内稳定性。它是否是滑膜切除术中使用的放射性核素的合适载体？

In vivo stability of ferric hydroxide macroaggregates (FHMA). Is it a suitable carrier for radionuclides used in synovectomy?

作者信息

Chinol M, Vallabhajosula S, Zuckerman J D, Goldsmith S J

机构信息

Department of Physics-Nuclear Medicine, Mount Sinai Medical Center, New York, NY 10029.

出版信息

Int J Rad Appl Instrum B. 1990;17(5):479-86. doi: 10.1016/0883-2897(90)90167-y.

DOI:10.1016/0883-2897(90)90167-y

PMID:2391243

Abstract

Ferric hydroxide macroaggregates (FHMA) have been widely used as a carrier for several radionuclides used in radiation synovectomy. Different rates of extra-articular leakage of radioactivity have been observed with 90Y and 165Dy. In order to understand the mechanism(s) involved in the extra-articular leakage of radioactivity, the in vivo stability of FHMA carrier was studied. Following an injection of [59Fe]Fe-FHMA into the knees of normal rabbits, the cumulative leakage of [59Fe]Fe-FHMA was 2.9% at 5 days and 12.3% at 14 days. More than 60% of this activity was in the blood. But when FHMA was double labeled with 59Fe and 166Ho, the 59Fe leakage significantly increased to 18.5% at 5 days and 27% by 14 days. The instability of FHMA is accelerated when it is complexed with 166Ho and may be due to the "mass effect" of 166Ho or due to radiolysis induced by high energy beta particles from 166Ho. These results suggest that FHMA is a suitable carrier only for the short lived radionuclides used in synovectomy.

摘要

氢氧化铁大颗粒聚集体（FHMA）已被广泛用作放射性滑膜切除术中使用的几种放射性核素的载体。使用90Y和165Dy时，观察到放射性物质关节外泄漏的速率不同。为了了解放射性物质关节外泄漏所涉及的机制，研究了FHMA载体在体内的稳定性。向正常兔膝关节注射[59Fe]Fe-FHMA后，[59Fe]Fe-FHMA的累积泄漏率在5天时为2.9%，在14天时为12.3%。该活性的60%以上存在于血液中。但是，当FHMA用59Fe和166Ho进行双重标记时，59Fe的泄漏在5天时显著增加到18.5%，到14天时增加到27%。当FHMA与166Ho络合时，其不稳定性会加速，这可能是由于166Ho的“质量效应”或166Ho产生的高能β粒子引起的辐射分解。这些结果表明，FHMA仅适用于滑膜切除术中使用的短寿命放射性核素的载体。