注射青霉素后发生大规模龟分枝杆菌脓肿亚种感染暴发。
Large-scale outbreak of infection with Mycobacterium chelonae subsp. abscessus after penicillin injection.
作者信息
Zhibang Yang, BiXia Zhang, Qishan Lu, Lihao Chen, Xiangquan Liu, Huaping Li
机构信息
Department of Microbiology, Chongqing University of Medical Science, Chongqing, People's Republic of China 400016.
出版信息
J Clin Microbiol. 2002 Jul;40(7):2626-8. doi: 10.1128/JCM.40.7.2626-2628.2002.
Abstract
An outbreak of infection with Mycobacterium chelonae subsp. abscessus after the injection of penicillin in 86 patients attending a factory hospital is reported. The bacterium was isolated both from lids and from the soil where the drug was stored. Molecular analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis of whole-cell proteins and plasmids revealed a pattern identical to that of the strains isolated from the wounds. The source of the infections was soil contamination of the vial lids and was caused by improper use and sterilization of penicillin vials.
摘要
据报道，一家工厂医院的86名患者在注射青霉素后发生了龟分枝杆菌脓肿亚种感染疫情。该细菌从瓶盖以及储存药物的土壤中均分离得到。通过十二烷基硫酸钠-聚丙烯酰胺凝胶电泳对全细胞蛋白和质粒进行分子分析，结果显示其图谱与从伤口分离出的菌株相同。感染源是药瓶瓶盖受到土壤污染，这是由于青霉素药瓶使用和灭菌不当所致。
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