Mostowy Serge, Cousins Debby, Brinkman Jacqui, Aranaz Alicia, Behr Marcel A
McGill University Health Centre, Montreal, Quebec, Canada.
J Infect Dis. 2002 Jul 1;186(1):74-80. doi: 10.1086/341068. Epub 2002 May 30.
To better understand the evolution of the Mycobacterium tuberculosis complex, subspecies were tested for large sequence polymorphisms. Samples with greater numbers of deletions, without exception, were missing all the same regions that were deleted from samples with lesser numbers of deletions. Principal genetic groups based on single-nucleotide polymorphisms were restricted to one of the deletion-based groups, and isolates that shared genotypes based on molecular epidemiological markers were assigned almost exclusively to the same deletion type. The data provide compelling evidence that human tuberculosis did not originate from the present-day bovine form. Genomic deletions present themselves as an attractive modality to study the evolution of the M. tuberculosis complex.
为了更好地理解结核分枝杆菌复合群的进化过程，对其亚种进行了大序列多态性检测。删除数量较多的样本无一例外地缺失了所有与删除数量较少的样本相同的区域。基于单核苷酸多态性的主要基因群局限于基于缺失的基因群之一，并且基于分子流行病学标记共享基因型的分离株几乎都被归为同一缺失类型。这些数据提供了令人信服的证据，表明人类结核病并非起源于现代牛型结核分枝杆菌。基因组缺失是研究结核分枝杆菌复合群进化的一种有吸引力的方式。
