Hermens W T, Witteveen S A, Hollaar L, Hemker H C
Recent Adv Stud Cardiac Struct Metab. 1975;10:319-29.
Using a two-compartment model with continuous input function, the rate and extent of myocardial damage were calculated from plasma enzyme levels measured in patients suffering from acute myocardial infarction (AMI). Results were compared for four different enzymes. As regards the course of necrosis, two different hypotheses were tested and it was shown that the necrotic process has to be considered as a mulitplicative process rather than as a sudden disintigration of cells due to anoxia. Comparison of results obtained in a group of 5 patients treated with urokianse and in an untreated control group of 10 patients showed that the necrotic phase as defined by the enzyme release from the infarcted area was significantly shortened.
使用具有连续输入函数的双室模型，根据急性心肌梗死（AMI）患者血浆酶水平计算心肌损伤的速率和程度。对四种不同的酶进行了结果比较。关于坏死过程，检验了两种不同的假设，结果表明坏死过程应被视为一个乘法过程，而不是由于缺氧导致细胞突然解体。对一组接受尿激酶治疗的5名患者和未治疗的10名患者对照组的结果进行比较，结果显示，由梗死区域释放的酶所定义的坏死期明显缩短。
