具有抗炎作用的间硝基苯甲酰天冬氨酸和间硝基苯甲酰天冬酰胺的新衍生物。
New derivatives of m-nitrobenzoyl-asparagic acid and m-nitrobenzoyl-asparagine with anti-inflammatory action.
作者信息
Filimon M, Năstasă V, Pavelescu M, Băsu C, Sunel V
机构信息
Help-Flux Pharmacy, Iaşi.
出版信息
Rev Med Chir Soc Med Nat Iasi. 2000 Oct-Dec;104(4):45-50.
PMID:12089958
Abstract
In order to obtain new biologically active compounds some derivatives of 1-[N-(m-nitrobenzoyl)-alpha-D,L-asparaginyl]-2-benzyl-benzimidazole have been synthesized by ring opening reactions of 2-(m-nitrophenyl)-4-(beta-amidomethyl)-delta 2-oxazolin-5-one and 2-(m-nitrophenyl)-4-(beta-carboxymethyl)-delta 2-oxazolin-5-one with 2-benzylbenzimidazole (dibazole).
摘要
为了获得新的生物活性化合物，通过2-(间硝基苯基)-4-(β-氨甲基)-δ2-恶唑啉-5-酮和2-(间硝基苯基)-4-(β-羧甲基)-δ2-恶唑啉-5-酮与2-苄基苯并咪唑（地巴唑）的开环反应，合成了1-[N-(间硝基苯甲酰基)-α-D,L-天冬酰胺基]-2-苄基-苯并咪唑的一些衍生物。
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