N-（间硝基苯甲酰基）-D，L-天冬酰胺的一些新型（磺酰胺基苯基）-酰胺衍生物的合成与毒性
[Synthesis and toxicity of some new (sulfon-amidophenyl)-amide derivatives of N-(m-nitrobenzoil)-D,L-asparagine].
作者信息
Sunel V, Ciobanu Anca, Profire Lenuţa, Băsu Cristina
机构信息
Universitatea Al. I. Cuza Iaşi, Facultatea de Chimie.
出版信息
Rev Med Chir Soc Med Nat Iasi. 2005 Jul-Sep;109(3):671-5.
PMID:16607771
Abstract
In order to obtain new compounds with potential antibacterial activity some new (sulfonamidophenyl)-amide derivatives of N-(m-nitrobenzoil)-D,L-asparagine have been synthesized. The compounds have been obtained by decyclization reaction of 2-(m-nitrophenyl)-4-(beta-amidomethyl)-delta2-oxazolinone with various sulfonamides. A toxicity study with determination of DL50 value has also been realized.
摘要
为了获得具有潜在抗菌活性的新化合物，已经合成了一些N-（间硝基苯甲酰基）-D，L-天冬酰胺的新型（磺酰胺基苯基）-酰胺衍生物。这些化合物是通过2-（间硝基苯基）-4-（β-酰胺基甲基）-δ2-恶唑啉酮与各种磺酰胺的开环反应得到的。还进行了一项测定半数致死剂量（DL50）值的毒性研究。
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