Vasconcellos Adriana, Villagrán Eduardo, Peña Patricio, Miska Werner, Sánchez Raúl
Departamentos de Ciencias Básicas, de Obstetricia y Ginecología, de Ciencias Preclínicas y Centro de Biotecnología en Reproducción, Facultad de Medicina, Universidad de La Frontera, Temuco, Chile.
Rev Med Chil. 2002 Apr;130(4):425-9.
Endometrial decidual reaction in postmenopausal women without an evident exogenous or endogenous progesterone stimulus, is uncommon. The morphological findings are decidual transformation of the endometrial stroma, necrosis, cellular pleomorphism and in some cases hyperplastic glands that exhibit focal atypia raising the possibility of malignancy. We report the case of a 55 years old woman with an idiopathic endometrial decidual reaction. In this woman, immunocytochemistry of endometrial tissue demonstrated the absence of cytoplasmatic and nuclear estrogen receptors. Staining of nuclear progesterone receptors and cytoplasmatic corticoid binding globulin, exceeded the immunoreactivity observed in any period of the menstrual cycle.
绝经后女性在无明显外源性或内源性孕激素刺激情况下出现子宫内膜蜕膜样反应并不常见。形态学表现为子宫内膜间质蜕膜样化生、坏死、细胞多形性,部分病例可见增生腺体伴局灶性异型性,提示有恶性可能。我们报告一例55岁患特发性子宫内膜蜕膜样反应的女性病例。该女性子宫内膜组织免疫细胞化学显示,胞质和细胞核雌激素受体均缺失。细胞核孕激素受体及胞质皮质类固醇结合球蛋白染色,超过了月经周期任何时期观察到的免疫反应性。