绝经后女性子宫内膜息肉及相邻子宫内膜中雌激素和孕激素受体的免疫组化表达
Immunohistochemical expression of estrogen and progesterone receptors in endometrial polyps and adjacent endometrium in postmenopausal women.
作者信息
Sant'Ana de Almeida Elza Carvalho, Nogueira Antonio Alberto, Candido dos Reis Francisco José, Zambelli Ramalho Leandra Náira, Zucoloto Sérgio
机构信息
Department of Gynecology and Obstetrics, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Av. Bandeirantes, no. 3900, 8o andar, Ribeirão Preto, São Paulo, CEP 14049-900, Brazil.
出版信息
Maturitas. 2004 Nov 15;49(3):229-33. doi: 10.1016/j.maturitas.2004.02.009.
OBJECTIVE
To detect the presence of estrogen (ER) and progesterone (PR) receptors in endometrial polyps and adjacent endometrium in postmenopausal women.
METHODS
Forty-four consecutively enrolled postmenopausal patients were submitted to operative hysteroscopy. These patients had diagnosed benign endometrial polyp. The presence of ER and PR was determined in endometrial samples and polyps by immunohistochemical method and the slides were evaluated using a semiquantitative analysis.
RESULTS
In the glandular epithelium, the median of the ER score was 7.0 in the polyps and 5.0 in the endometrium (P<0.0001) and the median of the PR was 6.0 in the polyps and 4.0 in the endometrium (P<0.0001). In the stroma, the median of the ER score was 6.0 in the polyps and 5.0 in the endometrium (P=0.021) and the median of the PR score was 4.0 in the polyps and 4.5 in the endometrium (P=0.34 ).
CONCLUSIONS
Our data suggests that steroids receptors present a crucial role in the phisiopathology of the endometrial polyps in postmenopausal women, specially the estrogen receptors.
目的
检测绝经后妇女子宫内膜息肉及相邻子宫内膜中雌激素（ER）和孕激素（PR）受体的存在情况。
方法
连续纳入44例绝经后患者，行宫腔镜手术。这些患者已诊断为良性子宫内膜息肉。采用免疫组织化学方法测定子宫内膜样本和息肉中ER和PR的存在情况，并使用半定量分析对切片进行评估。
结果
在腺上皮中，息肉中ER评分的中位数为7.0，子宫内膜中为5.0（P<0.0001）；息肉中PR的中位数为6.0，子宫内膜中为4.0（P<0.0001）。在间质中，息肉中ER评分的中位数为6.0，子宫内膜中为5.0（P=0.021）；息肉中PR评分的中位数为4.0，子宫内膜中为4.5（P=0.34）。
结论
我们的数据表明，类固醇受体在绝经后妇女子宫内膜息肉的病理生理过程中起关键作用，尤其是雌激素受体。
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