Vega K E, Hawk W A, Shirey E K, Osborne D G
Recent Adv Stud Cardiac Struct Metab. 1975;10:731-69.
Vesicular myocardial change is a specific and common finding in the diseased hearts of humans and experimental animals. The small to large vesicles are generally bound by a double membrane. They are formed within myocardial cells and then possibly extruded into the extracellular space where they disintegrate or are phagocytosed by mononuclear cells. On the basis of our studies, most vesicles appear to be of mitochonrial origin. In humans, vesicular myocardial change appears to be most extreme in primary cardiomyopathy. It may also be present, but in lesser degree, in the apparently normal hearts of human adults. Vesicular myocardial change probably represents a specific mechanism by which myocardial cells eliminate damage mitochondria or other undesirable elements that build within them as a result of disease, aging, and perhaps normal physiological activity.
水泡样心肌改变是人类和实验动物患病心脏中一种特定且常见的表现。大小不一的水泡通常由双层膜包绕。它们在心肌细胞内形成，然后可能被挤出到细胞外间隙，在那里它们会解体或被单核细胞吞噬。根据我们的研究，大多数水泡似乎起源于线粒体。在人类中，水泡样心肌改变在原发性心肌病中似乎最为明显。它也可能存在于成年人类看似正常的心脏中，但程度较轻。水泡样心肌改变可能代表了一种特定机制，通过该机制心肌细胞清除受损的线粒体或其他因疾病、衰老以及可能的正常生理活动而在细胞内积累的不良成分。
