Bacon Chris M, Du Ming-Qing, Dogan Ahmet
Department of Pathology, University of Cambridge, Cambridge, UK.
J Clin Pathol. 2007 Apr;60(4):361-72. doi: 10.1136/jcp.2005.031146. Epub 2006 Sep 1.
Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is the third most common non-Hodgkin lymphoma subtype, accounting for around 6-8% of all non-Hodgkin lymphomas in the Western hemisphere. Although MALT lymphomas are clinically indolent, the disease is typically chronic, requiring long-term clinical surveillance and, often, repeated biopsies. Pathologists thus play a central role in the diagnosis and management of these patients. The optimal diagnosis and management of a MALT lymphoma requires careful integration of morphological, immunohistochemical and molecular information, together with close cooperation with the clinician treating the patient. This review discusses recent developments in the molecular pathogenesis of MALT lymphoma and provides strategies for integrating this information into daily pathological practice.
黏膜相关淋巴组织结外边缘区淋巴瘤（MALT淋巴瘤）是第三常见的非霍奇金淋巴瘤亚型，在西半球占所有非霍奇金淋巴瘤的6 - 8%左右。尽管MALT淋巴瘤临床进展缓慢，但该疾病通常呈慢性过程，需要长期临床监测，且常常需要反复活检。因此，病理学家在这些患者的诊断和管理中起着核心作用。MALT淋巴瘤的最佳诊断和管理需要仔细整合形态学、免疫组化和分子信息，并与治疗患者的临床医生密切合作。本文综述讨论了MALT淋巴瘤分子发病机制的最新进展，并提供了将这些信息整合到日常病理实践中的策略。
