Garrett C Gaelyn, Reinisch Lou
Department of Otolaryngology, Vanderbilt Bill Wilkerson Center for Otolaryngology and Communication Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA.
Ann Otol Rhinol Laryngol. 2002 Jun;111(6):471-6. doi: 10.1177/000348940211100601.
We investigated wound healing of vocal fold mucosal excisions using a canine model, comparing cold steel, the continuous wave (CW) carbon dioxide (CO2) laser, and a new, microsecond-pulsed CO2 laser. The thermal injury to the surrounding normal tissues produced by the laser increases the risk for scar formation and poor functional voice outcome. This injury may be reduced with a pulsed CO2 laser. Acute, 2-week, and 6-week studies of 15 dogs were made with blinded observers and nonparametric statistical analyses. Histologic comparison showed less thermal injury and scar formation in the vocal folds treated with the pulsed CO2 laser than with the CW CO2 laser. Functional outcomes as studied with laryngeal videostroboscopy revealed better vibratory characteristics with the pulsed CO2 laser as compared with the CW CO2 laser. No differences were seen on these measures between the pulsed laser and cold techniques. Pulsed CO2 lasers may offer the ease of laser laryngology and the superior wound healing of cold steel.
我们使用犬类模型研究了声带黏膜切除术的伤口愈合情况，比较了冷钢刀、连续波（CW）二氧化碳（CO2）激光和一种新型微秒脉冲CO2激光。激光对周围正常组织造成的热损伤会增加瘢痕形成风险和导致不良的嗓音功能结果。使用脉冲CO2激光可能会减少这种损伤。对15只犬进行了急性、2周和6周的研究，由盲法观察者进行观察并采用非参数统计分析。组织学比较显示，与连续波CO2激光治疗的声带相比，脉冲CO2激光治疗的声带热损伤和瘢痕形成更少。通过喉动态镜检查研究的功能结果显示，与连续波CO2激光相比，脉冲CO2激光具有更好的振动特性。在这些指标上，脉冲激光与冷钢刀技术之间没有差异。脉冲CO2激光可能兼具激光喉科学的便捷性和冷钢刀的优异伤口愈合效果。
