Setchell B P, Plöen L, Ritzen E M
Pediatric Endocrinology Unit, Karolinska Hospital, Stockholm, Sweden.
Reproduction. 2002 Jul;124(1):133-40. doi: 10.1530/rep.0.1240133.
The effects of local heating of rat testes, in which spermatogenesis had been suppressed with injections of a GnRH agonist and an anti-androgen, were examined. Although the detrimental effects of heating were not as marked as those found in the testes of non-injected rats, the testes in which spermatogenesis was suppressed also showed a significant reduction in mass, the number of spermatozoa, tubular diameter and the percentage of normal tubular cross-sections at day 35 after heating. The results indicate that heating has an effect on cells in the testis other than those shown to be most susceptible to heat, namely pachytene spermatocytes and early spermatids, which were absent or markedly reduced in number when spermatogenesis was suppressed. The long-term effects of heating on the above parameters, as reported in a previous study, were also confirmed. However, in testes in which spermatogenesis was suppressed at the time of heating, there appeared to be no or a reduced long-term impairment of spermatogenesis, as determined by testis mass, the percentage of qualitatively normal tubules and epididymal sperm counts.
研究了对大鼠睾丸进行局部加热的效果，这些大鼠的精子发生已通过注射促性腺激素释放激素（GnRH）激动剂和抗雄激素而受到抑制。尽管加热的有害影响不如未注射大鼠睾丸中所发现的那么明显，但在加热后第35天，精子发生受到抑制的睾丸在质量、精子数量、管径以及正常管状横截面积百分比方面也出现了显著下降。结果表明，加热对睾丸中的细胞有影响，而不仅仅是那些已被证明对热最敏感的细胞，即粗线期精母细胞和早期精子细胞，当精子发生受到抑制时，这些细胞数量缺失或显著减少。先前一项研究中报道的加热对上述参数的长期影响也得到了证实。然而，在加热时精子发生受到抑制的睾丸中，根据睾丸质量、定性正常小管的百分比和附睾精子计数来判断，似乎不存在长期的精子发生损害或损害有所减轻。
