首发精神病中的颞叶异常。
Temporal lobe abnormalities in first-episode psychosis.
作者信息
Sumich Alex, Chitnis Xavier A, Fannon Dominic G, O'Ceallaigh Séamus, Doku Victor C, Falrowicz Abi, Marshall Nicolette, Matthew Vallakalil M, Potter Mark, Sharma Tonmoy
机构信息
Clinical Neuroscience Research Centre, Stonehouse Hospital, Cotton Lane, Dartford, Kent DA2 6AU, UK.
出版信息
Am J Psychiatry. 2002 Jul;159(7):1232-5. doi: 10.1176/appi.ajp.159.7.1232.
OBJECTIVE
The nature and time course of temporal lobe abnormalities in psychotic illness remain controversial. Confounds include disease chronicity, gender, and handedness. The present study investigated temporal substructures in right-handed male patients experiencing their first episode of psychotic illness.
METHOD
Magnetic resonance imaging scans were obtained for 25 minimally treated patients experiencing their first psychotic episode and 16 healthy comparison subjects. Group differences in volumes of the hippocampus, amygdala, planum temporale, and Heschl's gyrus were tested.
RESULTS
The patients had smaller bilateral hippocampal and left planum temporale volumes than the comparison subjects. Paranoid and nonparanoid patients differed in left amygdala volume.
CONCLUSIONS
The authors conclude that bilateral hippocampal and left planum temporale abnormalities are present near the onset of psychosis.
目的
精神病性疾病中颞叶异常的性质和时间进程仍存在争议。混杂因素包括疾病慢性化、性别和利手。本研究调查了首次发作精神病性疾病的右利手男性患者的颞叶亚结构。
方法
对25例首次发作精神病且治疗最少的患者和16名健康对照者进行磁共振成像扫描。测试海马体、杏仁核、颞平面和颞横回体积的组间差异。
结果
与对照者相比，患者双侧海马体和左侧颞平面体积较小。偏执型和非偏执型患者的左侧杏仁核体积不同。
结论
作者得出结论，双侧海马体和左侧颞平面异常在精神病发作初期就已存在。
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