Rootwelt K
Scand J Clin Lab Invest. 1975 Nov;35(7):649-53.
Thyroxine concentration, determined by competitive protein-binding radioassay (T4(D)), increased in serum stored at 20 degrees C and 37 degrees C. The increase correlated well with the increase in nonesterified fatty acids (NEFA). In vitro addition of NEFA to serum and in vivo increase in NEFA induced by post-prandial heparin injection resulted in a proportional increase in T4(D) values. Protein-bound iodine and thyroxine concentration, as determined by radioimmunoassay, were not influenced by storage and changes in NEFA concentration. NEFA interfere with T4(D), leading to elevated results.
通过竞争性蛋白结合放射分析法（T4(D)）测定的甲状腺素浓度，在20℃和37℃储存的血清中有所增加。这种增加与非酯化脂肪酸（NEFA）的增加密切相关。在体外向血清中添加NEFA以及餐后注射肝素诱导体内NEFA增加，均导致T4(D)值成比例增加。通过放射免疫分析法测定的蛋白结合碘和甲状腺素浓度不受储存和NEFA浓度变化的影响。NEFA干扰T4(D)，导致结果升高。
