Olsen L, Bäcklund L, Göransson M
Scand J Urol Nephrol. 1975;9(3):261-8. doi: 10.3109/00365597509134223.
Studies of backflow in experimental unilateral chronic hydronephrosis in dogs with a known residual renal function and renal pelvic volume were performed with radioactively labelled substances with molecular weights of ca. 600, 5 200 and 68 000 placed in the hydronephrotic renal pelvis. Three different pressure levels in the renal pelvis were used. Isotope concentrations were determined in the thoracic duct lymph, 0lood and urine from the contralateral kidney. The greater part of the test substances appeared to pass to the blood circulation, while a smaller part was found in the lymphatic ducts. The largest molecule, however, was only able to leave the renal pelvis to any appreciable extent at the highest pressure. In kidneys with a low grade of hydronephrosis and well preserved function, a relatively large amount of test substance left the renal pelvis (ca. 10-15%). In more advanced grades of hydronephrosis with greater impairment of renal function, the backflow was considerably less.
对已知残余肾功能和肾盂容量的实验性单侧慢性肾积水犬，将分子量约为600、5200和68000的放射性标记物质注入肾盂，进行逆流研究。肾盂使用了三种不同的压力水平。测定胸导管淋巴液、血液和对侧肾脏尿液中的同位素浓度。大部分受试物质似乎进入了血液循环，而在淋巴管中发现的较少。然而，最大的分子只有在最高压力下才能在任何可观程度上离开肾盂。在肾积水程度较轻且功能保存良好的肾脏中，相对大量的受试物质离开了肾盂（约10%-15%）。在肾积水程度更严重且肾功能损害更大的情况下，逆流则明显减少。
