Haulică I, Boişteanu D, Neagu B
Disciplina de Fiziologie, Facultatea de Medicină, Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi.
Rev Med Chir Soc Med Nat Iasi. 2001 Jan-Mar;105(1):11-8.
After a brief presentation of the data concerning the mechanism of production of oxidative stress as an expression of cellular and molecular stressing aggression, the main actions and functional implications of the excess of free radicals at the level of the main tissues and organs are presented. Emphasis is made on the nuclear, cytosolic and membrane alterations produced by the lipid peroxidation phenomena and the cell protein degradation induced by the oxidative stress. Special attention is given to the beneficial and harmful properties of the free radical species of oxygen and nitrogen, beginning with their involvement in the production of the normal adaptive reactions and ending with their involvement in the pathogenesis of various pathological states. In the group of beneficial effects are included along with the antibacterial and antiviral properties of the free radicals and their participation in the autoregulation of the local arteriolar-capillary circulation network. As harmful properties are mentioned the cellular destructive phenomena produced by the free radicals, which are considered as the generators of a true radicals pathology (senescence, atherogenesis, cancerogenesis, neurodegenerative diseases, etc).
在简要介绍了有关氧化应激产生机制的数据（作为细胞和分子应激侵袭的一种表现）之后，阐述了自由基过量在主要组织和器官层面的主要作用及功能影响。重点介绍了脂质过氧化现象引起的核、胞质和膜改变，以及氧化应激诱导的细胞蛋白质降解。特别关注了氧和氮自由基的有益和有害特性，从它们参与正常适应性反应的产生开始，到它们参与各种病理状态的发病机制结束。在有益作用组中，包括自由基的抗菌和抗病毒特性以及它们参与局部小动脉 - 毛细血管循环网络的自动调节。作为有害特性，提到了自由基产生的细胞破坏现象，这些现象被认为是真正的自由基病理学（衰老、动脉粥样硬化、癌症发生、神经退行性疾病等）的引发因素。
