Haulică I, Boişteanu P, Iliescu R
Catedra de Fiziologie, Universitatea de Medicină şi Farmacie Gr. T. Popa Iaşi.
Rev Med Chir Soc Med Nat Iasi. 2000 Apr-Jun;104(2):15-9.
After a short review of the literature concerning the paradox of oxygen and the participation of the oxidative stress created by the prevalence of its reactive radical species over the antioxidant enzymes, the main experimental arguments favoring the hypothesis of the implication of free radicals in senescence will be exposed. The amplification of degrading processes of lipid peroxidation and altering of the protein thiol groups in the presence of reactive oxygen species will be outlined. Both the aging of mitochondria due to the alteration of the electron transport chain and the oxidative attack on the mitochondrial DNA and the activation of the apoptosis as programmed cell death phenomenon in the presence of free radicals of oxygen, nitrogen and carbon will be given a particular interest. Finally, the implication of radical species in the production of some cardiovascular degenerative diseases of elderly patients will be discussed, together with the protective role of antioxidant compounds and diet, as factors that confine the progressive degradation of the senescent human body.
在简短回顾了有关氧悖论以及由其活性自由基种类在抗氧化酶之上占优势所产生的氧化应激参与的文献后，将阐述支持自由基参与衰老假说的主要实验依据。将概述在活性氧存在下脂质过氧化降解过程的放大以及蛋白质巯基的改变。由于电子传递链的改变导致的线粒体衰老、对线粒体DNA的氧化攻击以及在氧、氮和碳自由基存在下作为程序性细胞死亡现象的细胞凋亡激活都将受到特别关注。最后，将讨论自由基种类在老年患者一些心血管退行性疾病产生中的作用，以及抗氧化化合物和饮食的保护作用，它们是限制衰老人体进行性退化的因素。
