Ciornea L, Miron L, Ghiorghiu S
Facultatea de Medicină Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi, Clinica Radiologie-Oncologie, Spitalul Sf. Spiridon Iaşi.
Rev Med Chir Soc Med Nat Iasi. 2001 Jan-Mar;105(1):49-53.
The complexity of tobacco smoke leads to some confusion about mechanisms by with is caused lung cancer. Tobacco smoke contains many carcinogens, but 20 of them are deeply involved in causing lung cancer induction. Of these, polycyclic aromatic hydrocarbons and tobacco specific nitrosamine are likely to play a major role. This review include a discussion of the mechanisms of interaction between DNA and tobacco smoke carcinogens and the relationships with mutations in oncogenes and tumor suppressor genes. By focusing in this review on several important carcinogens in tobacco smoke, the complexities in understanding tobacco-induced cancer can be reduced, and new approaches for lung cancer prevention can be envisioned.
烟草烟雾的复杂性导致了人们对其引发肺癌机制的一些困惑。烟草烟雾含有许多致癌物，但其中20种与肺癌诱导密切相关。其中，多环芳烃和烟草特异性亚硝胺可能起主要作用。本综述讨论了DNA与烟草烟雾致癌物之间的相互作用机制以及与癌基因和抑癌基因突变的关系。通过在本综述中聚焦于烟草烟雾中的几种重要致癌物，可以减少理解烟草诱导癌症的复杂性，并设想预防肺癌的新方法。
