Hecht S S
American Health Foundation, Valhalla, New York 10595, USA.
Prev Med. 1996 Jan-Feb;25(1):7-9. doi: 10.1006/pmed.1996.0004.
Carcinogen-derived biomarkers are substances such as metabolites or macromolecular adducts that are derived from specific identifiable carcinogens and can be quantified in human tissues or body fluids. With respect to lung cancer, the most important carcinogen-derived biomarkers presently being studied are those derived from the lung carcinogens in tobacco smoke-4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and polynuclear aromatic hydrocarbons. Some examples of these biomarkers and their application are discussed.
致癌物衍生的生物标志物是诸如代谢物或大分子加合物之类的物质，它们源自特定的可识别致癌物，并且可以在人体组织或体液中进行定量分析。就肺癌而言，目前正在研究的最重要的致癌物衍生生物标志物是那些源自烟草烟雾中的肺癌致癌物——4-（甲基亚硝胺基）-1-（3-吡啶基）-1-丁酮和多环芳烃的生物标志物。本文将讨论这些生物标志物的一些实例及其应用。
