Johnston I, Kollar C, Dunkley S, Assaad N, Parker G
Department of Surgery, University of Sydney, Sydney, Australia.
J Clin Neurosci. 2002 May;9(3):273-8. doi: 10.1054/jocn.2001.0986.
This study reports a retrospective analysis of the evidence of cranial venous outflow pathology in 188 patients with pseudotumour syndrome (PTS) investigated over the period 1968-1999. Standard methods of investigation appropriate to the period were used, i.e. cerebral angiography, CT and MR scanning. Recently, some patients had specific venous studies including intraluminal cranial venous sinus pressure measurements. A sub-group (25 patients) was investigated for haematological abnormalities. The overall incidence of cranial venous outflow abnormality was 19.7% (37 cases). In decades, related to the predominant investigative method, the figures were: to 1979, 4.2% (2 cases); to 1989, 15.0% (8 cases); to 1999, 31.0% (27 cases). A cause of the venous abnormality was identified in 20 cases, most commonly haematological and iatrogenic. In 17 patients (all females) no cause was identified. Fifteen of the 25 patients (60%) tested specifically were found to have a haematological abnormality, although no correlation was shown between this and a demonstrable venous outflow abnormality. The conclusion was drawn that there is a high incidence (close to one-third) of venous outflow abnormalities in PTS with detailed investigation. Issues of mechanism and therapy are discussed.
本研究报告了对1968年至1999年间接受调查的188例假瘤综合征（PTS）患者的颅静脉流出道病变证据进行的回顾性分析。采用了该时期适用的标准调查方法，即脑血管造影、CT和磁共振扫描。最近，一些患者进行了特定的静脉研究，包括腔内颅静脉窦压力测量。对一个亚组（25例患者）进行了血液学异常调查。颅静脉流出道异常的总体发生率为19.7%（37例）。按十年划分，与主要调查方法相关的数据如下：到1979年，4.2%（2例）；到1989年，15.0%（8例）；到1999年，31.0%（27例）。在20例中确定了静脉异常的原因，最常见的是血液学和医源性原因。在17例患者（均为女性）中未发现原因。在专门检测的25例患者中，有15例（60%）发现有血液学异常，尽管这与可证实的静脉流出道异常之间未显示出相关性。得出的结论是，经过详细调查，PTS患者中静脉流出道异常的发生率很高（接近三分之一）。并讨论了发病机制和治疗问题。
