从红皮云杉中分离得到的一种新型ACAT抑制性三萜——红皮云杉酸A。

Aceriphyllic acid A, A new ACAT inhibitory triterpenoid, from Aceriphyllum rossii.

作者信息

Han Jae-Taek, Kim Hae-Yeong, Park Young-Doo, Lee Youn-Hyung, Lee Kang-Ro, Kwon Byoung-Mog, Baek Nam-In

出版信息

Planta Med. 2002 Jun;68(6):558-61. doi: 10.1055/s-2002-32565.

DOI:10.1055/s-2002-32565

PMID:12094307

Abstract

Two new triterpenoids along with three known ones, 3-oxoolean-12-en-27-oic acid (1), 3alpha-hydroxyolean-12-en-27-oic acid (2) and 3beta-hydroxyolean-12-en-27-oic acid (3), were isolated from Aceriphyllum rossii. The structures of the new compounds were determined to be a 3alpha,23-dihydroxyolean-12-en-27-oic acid (4) and a 3alpha,23-dihydroxyolean-12-en-29-oic acid (5) by spectroscopic and chemical methods; they were designated aceriphyllic acids A and B, respectively. Compounds 2, 3 and 4 remarkably inhibited the activity of ACAT.

摘要

从红脉槭中分离出两种新的三萜类化合物以及三种已知化合物，即3-氧代齐墩果-12-烯-27-酸（1）、3α-羟基齐墩果-12-烯-27-酸（2）和3β-羟基齐墩果-12-烯-27-酸（3）。通过光谱和化学方法确定新化合物的结构分别为3α,23-二羟基齐墩果-12-烯-27-酸（4）和3α,23-二羟基齐墩果-12-烯-29-酸（5）；它们分别被命名为红脉槭酸A和红脉槭酸B。化合物2、3和4显著抑制了ACAT的活性。