Saarinen N M, Huovinen R, Wärri A, Mäkelä S I, Valentín-Blasini L, Needham L, Eckerman C, Collan Y U, Santti R
Department of Anatomy, Institute of Biomedicine, University of Turku, FIN-20520 Turku, Finland.
Nutr Cancer. 2001;41(1-2):82-90. doi: 10.1080/01635581.2001.9680616.
The chemopreventive effects of hydroxymatairesinol (HMR), a lignan extracted from Norway spruce (Picea abies), on the development of mammary carcinoma induced by 7,12-dimethylbenz[a]anthracene (DMBA) was studied in rats. HMR administered via diet in an average daily dose of 4.7 mg/kg body wt starting before DMBA induction reduced tumor volume and tumor growth, but no significant reduction in tumor multiplicity (number of tumors/rat) was observed. The predominant histological type in the control group was type B (well-differentiated adenocarcinoma, 78%). The proportion of type B tumors decreased to 35% in the HMR group, while the type A (poorly differentiated) and type C (atrophic) tumor proportions increased. Anticarcinogenic effects of dietary HMR (4.7 mg/kg) were also evident when the administration started after DMBA induction and was seen as growth inhibition of established tumors. Dietary HMR supplementation significantly increased serum and urinary enterolactone and HMR concentrations but had no significant effect on the uterine weight, suggesting that HMR or its major metabolite enterolactone did not have an antiestrogenic effect. Further studies are warranted to further clarify and verify HMR action and the associated mechanisms in mammary tumorigenesis.
对从挪威云杉（Picea abies）中提取的木脂素羟基matairesinol（HMR）对7,12 - 二甲基苯并[a]蒽（DMBA）诱导的大鼠乳腺癌发生的化学预防作用进行了研究。在DMBA诱导前开始，以平均每日剂量4.7 mg/kg体重通过饮食给予HMR，可减小肿瘤体积并抑制肿瘤生长，但未观察到肿瘤多发性（每只大鼠的肿瘤数量）有显著降低。对照组中主要的组织学类型为B型（高分化腺癌，78%）。在HMR组中，B型肿瘤的比例降至35%，而A型（低分化）和C型（萎缩性）肿瘤的比例增加。当在DMBA诱导后开始给予饮食HMR（4.7 mg/kg）时，其抗癌作用也很明显，表现为对已形成肿瘤的生长抑制。饮食中补充HMR可显著提高血清和尿液中肠内酯和HMR的浓度，但对子宫重量没有显著影响，这表明HMR或其主要代谢产物肠内酯没有抗雌激素作用。有必要进行进一步研究以进一步阐明和验证HMR在乳腺肿瘤发生中的作用及相关机制。
